Potential Role of Hydroxyapatite Nanocrystalline for Early Diagnostics of Ovarian Cancer

Chyzhma, Ruslana Anatoliivna; Piddubnyi, Artem Mykhailovych; Danylchenko, Serhii Mykolaiovych; Kravtsova, Olha Ivanivna; Moskalenko, Roman Andriiovych

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Title	Potential Role of Hydroxyapatite Nanocrystalline for Early Diagnostics of Ovarian Cancer
Authors	Chyzhma, Ruslana Anatoliivna Piddubnyi, Artem Mykhailovych Danylchenko, Serhii Mykolaiovych Kravtsova, Olha Ivanivna Moskalenko, Roman Andriiovych
ORCID	http://orcid.org/0000-0002-6508-0131 http://orcid.org/0000-0002-2342-0337
Keywords	гідроксиапатит гидроксиапатит hydroxyapatite кальцифікати кальцификаты calcification рак яєчника рак яичников ovarian cancer рання діагностика ранняя диагностика early diagnostics
Type	Article
Date of Issue	2021
URI	https://essuir.sumdu.edu.ua/handle/123456789/85468
Publisher	MDPI
License	Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International
Citation	Chyzhma, R., Piddubnyi, A., Danilchenko, S., Kravtsova, O., Moskalenko, R. Potential Role of Hydroxyapatite Nanocrystalline for Early Diagnostics of Ovarian Cancer. Diagnostics 2021, 11, 1741. https://doi.org/10.3390/diagnostics11101741
Abstract	Calcification is one of the clinical and morphological manifestations of ovarian tumors and it begins at the initial stages of carcinogenesis. Thus, this process can be used for the early diagnostics of some malignant ovarian tumors. We compared the results of ultrasound and histology and found that calcifications of a size less than 200 µm are not detected by ultrasound. These calcified structures are round fragile particles of different sizes. In the EDX (Energy-dispersive X-ray spectroscopy) spectra, the main lines were from Ca and P, and the ratio of these elements corresponds to hydroxyapatite. Thus, we established that hydroxyapatite is the main mineral component of ovarian psammoma bodies and could be used for early diagnostics of ovarian malignant neoplasia
Appears in Collections:	Наукові видання (НН МІ)