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Title Complementary Effect of Non-Persistent Silver Nano- Architectures and Chlorhexidine on Infected Wound Healing
Authors Pernakov, Mykola Stanislavovych  
Ermini, M.L.
Sulaieva, O.
Cassano, D.
Santucci, M.
Husak, Yevheniia Volodymyrivna  
Korniienko, Viktoriia Volodymyrivna  
Giannone, G.
Yusupova, Aziza Farkhodivna
Liubchak, Iryna Volodymyrivna
Hristova, M.T.
Savchenko, A.
Holubnycha, Viktoriia Mykolaivna  
Voliani, V.
Pohorielov, Maksym Volodymyrovych  
Keywords antimicrobials
surgical site infections
silver
nanomaterials
wound healing
Type Article
Date of Issue 2021
URI https://essuir.sumdu.edu.ua/handle/123456789/86267
Publisher MDPI
License Creative Commons Attribution 4.0 International License
Citation Pernakov, M.; Ermini, M.L.; Sulaieva, O.; Cassano, D.; Santucci, M.; Husak, Y.; Korniienko, V.; Giannone, G.; Yusupova, A.; Liubchak, I.; Hristova, M.T.; Savchenko, A.; Holubnycha, V.; Voliani, V.; Pogorielov, M. Complementary Effect of Non-Persistent Silver Nano-Architectures and Chlorhexidine on Infected Wound Healing. Biomedicines 2021, 9, 1215. https://doi.org/10.3390/biomedicines9091215
Abstract Surgical site infection (SSI) substantially contributes each year to patients’ morbidity and mortality, accounting for about 15% of all nosocomial infections. SSI drastically increases the rehab stint and expenses while jeopardizing health outcomes. Besides prevention, the treatment regime relies on an adequate antibiotic therapy. On the other hand, resistant bacterial strains have currently reached up to 34.3% of the total infections, and this percentage grows annually, reducing the efficacy of the common treatment schemes. Thus, new antibacterial strategies are urgently demanded. Here, we demonstrated in rats the effectiveness of non-persistent silver nano-architectures (AgNAs) in infected wound healing together with their synergistic action in combination with chlorhexidine. Besides the in vivo efficacy evaluation, we performed analysis of the bacteriological profile of purulent wound, histological evaluations, and macrophages polarization quantifications to further validate our findings and elucidate the possible mechanisms of AgNAs action on wound healing. These findings open the way for the composition of robust multifunctional nanoplatforms for the translation of safe and efficient topical treatments of SSI.
Appears in Collections: Наукові видання (МІ)

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