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Title | The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level |
Authors |
Kolomiiets, Olena Olehivna
Yazykov, Oleksandr Valeriiovych Piddubnyi, Artem Mykhailovych Lyndin, Mykola Serhiiovych Lukavenko, Ivan Mykhailovych Andriushchenko, Volodymyr Viktorovych Romaniuk, Anatolii Mykolaiovych Moskalenko, Roman Andriiovych |
ORCID |
http://orcid.org/0000-0002-6464-4839 http://orcid.org/0000-0003-3528-9265 http://orcid.org/0000-0002-6508-0131 http://orcid.org/0000-0003-4385-3903 http://orcid.org/0000-0003-1302-1698 http://orcid.org/0000-0003-2560-1382 http://orcid.org/0000-0002-2342-0337 |
Keywords |
пролактин prolactin рецептори пролактину рецепторы пролактина prolactin receptors доброякісні пухлини грудної залози доброкачественные опхоли грудной железы benign breast tumors |
Type | Article |
Date of Issue | 2021 |
URI | https://essuir.sumdu.edu.ua/handle/123456789/86327 |
Publisher | MDPI |
License | Creative Commons Attribution 4.0 International License |
Citation | Kolomiiets, O.; Yazykov, O.; Piddubnyi, A.; Lyndin, M.; Lukavenko, I.; Andryushchenko, V.; Romaniuk, A.; Moskalenko, R. The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level. J. Clin. Med. 2021, 10, 5866. https://doi.org/10.3390/jcm10245866. |
Abstract |
The role of prolactin (PRL) and its receptors in the initiation and development of benign
breast tumors (BBT) has not been sufficiently studied. An imbalance in the system of hormone
homeostasis is crucial in the development of BBT. In particular, an association between elevated
prolactin levels and the development of BBT has been reported. Our study showed no significant
differences between PRL receptor (PRL-R) expression in BBT tissue under normal and elevated serum
PRL levels. There was also no significant correlation between age, PRL-R expression in BBT tissue,
intact tissue, and PRL level in the serum. There was a strong significant correlation (p < 0.01; r = 0.92)
between PRL-R expression in BBT samples and intact breast tissue, which did not depend on the
serum PRL level. There was also no significant difference in the expression of the proliferative marker
Ki-67 in BBT tissues from women with normal and elevated levels of serum PRL (p > 0.05). No signs
of PRL and its receptors were detected in the BBT cystic fluid women with elevated serum PRL levels.
In summary, our prospective study showed that the expression of PRL-R in the tissue of BBT and
physiological breast tissue does not depend on the level of serum PRL. |
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