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Title The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level
Authors Kolomiiets, Olena Olehivna  
Yazykov, Oleksandr Valeriiovych  
Piddubnyi, Artem Mykhailovych  
Lyndin, Mykola Serhiiovych  
Lukavenko, Ivan Mykhailovych  
Andriushchenko, Volodymyr Viktorovych
Romaniuk, Anatolii Mykolaiovych  
Moskalenko, Roman Andriiovych  
ORCID http://orcid.org/0000-0002-6464-4839
http://orcid.org/0000-0003-3528-9265
http://orcid.org/0000-0002-6508-0131
http://orcid.org/0000-0003-4385-3903
http://orcid.org/0000-0003-1302-1698
http://orcid.org/0000-0003-2560-1382
http://orcid.org/0000-0002-2342-0337
Keywords пролактин
prolactin
рецептори пролактину
рецепторы пролактина
prolactin receptors
доброякісні пухлини грудної залози
доброкачественные опхоли грудной железы
benign breast tumors
Type Article
Date of Issue 2021
URI https://essuir.sumdu.edu.ua/handle/123456789/86327
Publisher MDPI
License Creative Commons Attribution 4.0 International License
Citation Kolomiiets, O.; Yazykov, O.; Piddubnyi, A.; Lyndin, M.; Lukavenko, I.; Andryushchenko, V.; Romaniuk, A.; Moskalenko, R. The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level. J. Clin. Med. 2021, 10, 5866. https://doi.org/10.3390/jcm10245866.
Abstract The role of prolactin (PRL) and its receptors in the initiation and development of benign breast tumors (BBT) has not been sufficiently studied. An imbalance in the system of hormone homeostasis is crucial in the development of BBT. In particular, an association between elevated prolactin levels and the development of BBT has been reported. Our study showed no significant differences between PRL receptor (PRL-R) expression in BBT tissue under normal and elevated serum PRL levels. There was also no significant correlation between age, PRL-R expression in BBT tissue, intact tissue, and PRL level in the serum. There was a strong significant correlation (p < 0.01; r = 0.92) between PRL-R expression in BBT samples and intact breast tissue, which did not depend on the serum PRL level. There was also no significant difference in the expression of the proliferative marker Ki-67 in BBT tissues from women with normal and elevated levels of serum PRL (p > 0.05). No signs of PRL and its receptors were detected in the BBT cystic fluid women with elevated serum PRL levels. In summary, our prospective study showed that the expression of PRL-R in the tissue of BBT and physiological breast tissue does not depend on the level of serum PRL.
Appears in Collections: Наукові видання (НН МІ)

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