Please use this identifier to cite or link to this item: https://essuir.sumdu.edu.ua/handle/123456789/87382
Or use following links to share this resource in social networks: Recommend this item
Title Structural changes of long tubular bones of mature rats under the hyperglycemia
Authors Ponyrko, Alina Oleksiivna  
Bumeister, Valentyna Ivanivna  
Dmytruk, Serhii Mykolaiovych  
Yarmolenkо, Olha Serhiivna  
Teslyk, Tetiana Petrivna  
Riabenko, Tetiana Vasylivna  
Shkolna, Iryna Ivanivna  
ORCID http://orcid.org/0000-0002-1799-7789
http://orcid.org/0000-0001-8604-4458
http://orcid.org/0000-0001-6434-2817
http://orcid.org/0000-0002-7872-2308
http://orcid.org/0000-002-5832-7415
http://orcid.org/0000-0003-2740-389X
http://orcid.org/0000-0001-6756-0158
Keywords hyperglycemia
tubular bones
microarchitecture
Type Article
Date of Issue 2021
URI https://essuir.sumdu.edu.ua/handle/123456789/87382
Publisher ALUNA Publishing House
License Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International
Citation Ponyrko AO, Bumeister VI, Dmytruk SM, Yarmolenko OS, Teslyk TP, Riabenko TV, Shkolna I. Structural changes of long tubular bones of mature rats under the hyperglycemia. Wiad Lek. 2021;74(9 p.I):2052-2059. DOI: 10.36740/WLek202109105
Abstract The aim: To evaluate morphological changes in long tubular bones of mature rats under the influence of experimental hyperglycemia. Materials and methods: The study was conducted on 140 nonlinear white male rats divided into two groups. The experimental group included rats that were introduced into a state of hyperglycemia by a single intraperitoneal injection of an alloxan dihydrate solution at a dose of 150 mg / kg body weight in 0.9% sodium chloride. The control group included rats that were injected with a similar volume of 0.9% sodium chloride one time intraperitoneally. The animals were taken out of the experiment on the 2nd, 30th, 60th, 90th, 120th, 150th and 180th day. Right and left femur and humerus were studied by morphometric and histological methods. Results: Under conditions of prolonged uncontrolled hyperglycemia in mature rats, there is a slowdown in the growth rate of length and thickness of femur and humerus. This is indicated by a significant decrease in the length of bone and its diaphyses, as well as by a decrease in the cross-sectional area of the diaphysis, the width of the proximal and distal epiphyses, starting from 120 and 90 days of the experiment, respectively. The relative area of trabecular tissue, thickness of trabeculae and epiphyseal cartilage decreases in comparison with animals of the control group. The diameter of osteons and their channels increases in cortical tissue. Changes in the microarchitecture of the trabecular and cortical compartments of femur and humerus under conditions of hyperglycemia are similar and are characterized by a reduced bone mass, bone disorder progression and remodeling disorders. Conclusions: Prolonged uncontrolled experimental hyperglycemia leads to slow growth of femur and humerus in mature rats, which is accompanied by an increase in microarchitecture disorder of the trabecular and cortical compartments, causing miniaturization of bones and, consequently, violation of their biomechanical properties and increased risk of fractures.
Appears in Collections: Наукові видання (НН МІ)

Views

Argentina Argentina
1
Australia Australia
1
China China
136906268
Côte d’Ivoire Côte d’Ivoire
1
Finland Finland
2052978
Germany Germany
159723979
Greece Greece
1
Ireland Ireland
4103221
Lithuania Lithuania
1
Netherlands Netherlands
900803
Russia Russia
615
Singapore Singapore
-2016996507
South Africa South Africa
-2016996509
Sweden Sweden
9751
Ukraine Ukraine
-981365537
United Kingdom United Kingdom
623382971
United States United States
105079901
Unknown Country Unknown Country
-1756022232
Vietnam Vietnam
19504

Downloads

France France
1
Germany Germany
5093
Ireland Ireland
4103220
Lithuania Lithuania
1
Netherlands Netherlands
425
Singapore Singapore
1
South Africa South Africa
-2016996508
Sweden Sweden
1
Ukraine Ukraine
-981365536
United Arab Emirates United Arab Emirates
-981365537
United Kingdom United Kingdom
1
United States United States
-981365538
Unknown Country Unknown Country
-1756022231
Vietnam Vietnam
1

Files

File Size Format Downloads
Ponyrko_Structural_changes.pdf 230.87 kB Adobe PDF 1876927986

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.