Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population

Pohorielova, Oksana Serhiivna; Korniienko, Viktoriia Volodymyrivna; Chumachenko, Yaroslav Dmytrovych; Obukhova, Olha Anatoliivna; Martsovenko, I.; Harbuzova, Viktoriia Yuriivna

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Title	Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population
Authors	Pohorielova, Oksana Serhiivna Korniienko, Viktoriia Volodymyrivna Chumachenko, Yaroslav Dmytrovych Obukhova, Olha Anatoliivna Martsovenko, I. Harbuzova, Viktoriia Yuriivna
ORCID	http://orcid.org/0000-0003-4077-8637 http://orcid.org/0000-0002-5144-2138 http://orcid.org/0000-0002-4803-5435 http://orcid.org/0000-0002-2104-8412 http://orcid.org/0000-0001-7183-6997
Keywords	coronary artery disease chronic coronary syndrome Ukrainian population
Type	Article
Date of Issue	2022
URI	https://essuir.sumdu.edu.ua/handle/123456789/87770
Publisher	Hindawi
License	Creative Commons Attribution 4.0 International License
Citation	Oksana S. Pogorielova, Viktoriia V. Korniienko, Yaroslav D. Chumachenko, Olha A. Obukhova, Igor Martsovenko, Viktoriia Yu. Harbuzova, "Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population", Cardiology Research and Practice, vol. 2022, Article ID 2067632, 8 pages, 2022. https://doi.org/10.1155/2022/2067632
Abstract	Coronary artery disease (CAD) is one of the leading causes of death in Europe. It is known that atherosclerosis is the primary risk factor of CAD development. MMP-9 is involved in all stages of atherosclerosis and thus may contribute to CAD emergence. To investigate the influence of MMP-9 on the (CAD) development, 25 patients with intact coronary arteries (CA), 40 patients with acute coronary syndrome (ACS), and 63 patients with chronic coronary syndrome (CCS) were enrolled in the study. Real-time PCR was carried out for genotyping on the rs17567-polymorphic locus, and ELISA study was performed to measure the MMP-9 plasma concentration. It was found the lower risk of MI occurrence for AG-carriers (Pa = 0.023; ORa = 0.299, 95% CI = 0.106–0.848) in Ukrainian population.
Appears in Collections:	Наукові видання (НН МІ)