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Title Morphological features of tubular bones reparative regeneration under the influence of antitumor chemotherapeutics
Authors Riabenko, Tetiana Vasylivna  
Korenkov, Oleksii Volodymyrovych  
Dmytruk, Serhii Mykolaiovych  
Yarmolenkо, Olha Serhiivna  
Ponyrko, Alina Oleksiivna  
Pernakov, Mykola Stanislavovych  
Hula, Viktoriia Ivanivna  
ORCID http://orcid.org/0000-0003-2740-389X
http://orcid.org/0000-0002-1314-5642
http://orcid.org/0000-0001-6434-2817
http://orcid.org/0000-0002-7872-2308
http://orcid.org/0000-0002-1799-7789
http://orcid.org/0000-0002-7048-7446
http://orcid.org/0000-0003-3869-5162
Keywords reparative regeneration
bone
antitumor chemotherapeutics
Type Article
Date of Issue 2022
URI https://essuir.sumdu.edu.ua/handle/123456789/87865
Publisher Aluna Publishing
License Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International
Citation Riabenko ТV, Korenkov OV, Dmytruk SM, Yarmolenko OS, Ponurko AA, Pernakov MS, Gula VI. MORPHOLOGICAL FEATURES OF TUBULAR BONES REPARATIVE REGENERATION UNDER THE INFLUENCE OF ANTITUMOR CHEMOTHERAPEUTICS. Wiad Lek. 2022;75(3):570-576.
Abstract The aim: Determination of morphological features of reparative regeneration of diaphysis defect of long tubular bones under the influence of antitumor chemotherapeutics in a model experiment. Materials and methods: 96 white nonlinear rats after application of the perforated defect of the femur were administered the appropriate antitumor drug (doxorubicin, 5-fluorouracil, methotrexate) three times with an interval of 21 days. Morphological features of bone tissue formation and remodeling in the regenerate area were studied using histological and morphometric methods. Results: The inhibitory effect of antitumor chemotherapeutics on the formation of regenerate, expressed by slowing down the process of bone tissue differentiation was found. This is confirmed by a decrease in the area of reticulofibrous and lamellar bone tissue, chaotic arrangement and narrowing of bone trabeculae with uneven color, slow formation of bonding lines between the maternal bone and the regenerate. Conclusions: The revealed morphological features of reparative regeneration of the diaphysis defect of long tubular bones under the influence of antitumor chemotherapeutics doxorubicin, 5-fluorouracil and methotrexate in a model experiment indicate a slowing of reparative regeneration processes at all stages of recovery after injury.
Appears in Collections: Наукові видання (НН МІ)

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