Please use this identifier to cite or link to this item:
Or use following links to share this resource in social networks: Recommend this item
Title Impact of Electrospinning Parameters and Post-Treatment Method on Antibacterial and Antibiofilm Activity of Chitosan Nanofibers
Authors Korniienko, Viktoriia Volodymyrivna  
Husak, Yevheniia Volodymyrivna  
Radwan-Praglowska, J.
Holubnycha, Viktoriia Mykolaivna  
Samokhin, Yevhen Oleksandrovych
Yanovska, Hanna Oleksandrivna  
Varava, Yuliia Valentynivna
Diedkova, Kateryna Andriivna
Janus, L.
Pohorielov, Maksym Volodymyrovych  
Keywords natural products
chitosan electrospinning
antibacterial biomaterials
Type Article
Date of Issue 2022
Publisher MDPI
License Creative Commons Attribution 4.0 International License
Citation Korniienko, V.; Husak, Y.; Radwan-Pragłowska, J.; Holubnycha, V.; Samokhin, Y.; Yanovska, A.; Varava, J.; Diedkova, K.; Janus, Ł.; Pogorielov, M. Impact of Electrospinning Parameters and Post-Treatment Method on Antibacterial and Antibiofilm Activity of Chitosan Nanofibers. Molecules 2022, 27, 3343.
Abstract Chitosan, a natural biopolymer, is an ideal candidate to prepare biomaterials capable of preventing microbial infections due to its antibacterial properties. Electrospinning is a versatile method ideally suited to process biopolymers with minimal impact on their physicochemical properties. However, fabrication parameters and post-processing routine can affect biological activity and, therefore, must be well adjusted. In this study, nanofibrous membranes were prepared using trifluoroacetic acid and dichloromethane and evaluated for physiochemical and antimicrobial properties. The use of such biomaterials as potential antibacterial agents was extensively studied in vitro using Staphylococcus aureus and Escherichia coli as test organisms. The antibacterial assay showed inhibition of bacterial growth and eradication of the planktonic cells of both E. coli and S. aureus in the liquid medium for up to 6 hrs. The quantitative assay showed a significant reduction in bacteria cell viability by nanofibers depending on the method of fabrication. The antibacterial properties of these biomaterials can be attributed to the structural modifications provided by co-solvent formulation and application of post-treatment procedure. Consequently, the proposed antimicrobial surface modification method is a promising technique to prepare biomaterials designed to induce antimicrobial resistance via antiadhesive capability and the biocide-releasing mechanism.
Appears in Collections: Наукові видання (МІ)


Côte d’Ivoire Côte d’Ivoire
Ireland Ireland
Ukraine Ukraine
United Kingdom United Kingdom
United States United States
Unknown Country Unknown Country
Vietnam Vietnam


China China
Germany Germany
Ukraine Ukraine
United States United States
Unknown Country Unknown Country
Vietnam Vietnam


File Size Format Downloads
Korniienko_et_al_Electrospinning_Parameters_2022.pdf 6,63 MB Adobe PDF 23547

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.