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Title Response to neoadjuvant chemotherapy in breast cancer: do microRNAs matter?
Authors Ryspayeva, D.
Halytskiy, V.
Kobyliak, N.
Dosenko, I.
Fedosov, A.
Inomistova, M.
Drevytska, T.
Gurianov, V.
Sulaieva, Oksana Mykolaivna  
ORCID http://orcid.org/0000-0002-9614-4652
Keywords Resectable breast cancer
Neoadjuvant chemotherapy
Response to therapy
microRNA
miR-124
miR137
miR-34a
miR-155
miR-373
Type Article
Date of Issue 2022
URI https://essuir.sumdu.edu.ua/handle/123456789/88012
Publisher Springer
License Creative Commons Attribution 4.0 International License
Citation Ryspayeva, D., Halytskiy, V., Kobyliak, N. et al. Response to neoadjuvant chemotherapy in breast cancer: do microRNAs matter?. Discov Onc 13, 43 (2022). https://doi.org/10.1007/s12672-022-00507-z
Abstract Background Conventionally, breast cancer (BC) prognosis and prediction of response to therapy are based on TNM staging, histological and molecular subtype, as well as genetic alterations. The role of various epigenetic factors has been elucidated in carcinogenesis. However, it is still unknown to what extent miRNAs afect the response to neoadjuvant chemotherapy (NACT). This pilot study is focused on evaluating the role of miR-34a, miR-124a, miR-155, miR-137 and miR-373 in response to NACT. Methods That was a prospective study enrolling 34 patients with histologically confrmed BC of II-III stages. The median age of patients was 53 (47–59.8) years old, 70.6% of whom were HR-positive. MiRs levels were measured in the primary tumor before and after NACT. The response to therapy was assessed after surgery using the Miller-Payne scoring system. To establish the role of miRs in modulating response to NACT the Cox model was applied for analysis. Results BC demonstrated a great variability of miRs expression before and after NACT with no strong links to tumor stage and molecular subtype. Only miR-124a and miR-373 demonstrated differential expression between malignant and normal breast tissues before and after therapy though these distinctions did not impact response to NACT. Besides miR-124a and miR-137 levels after NACT were found to be dependent on HR status. While miR-124a levels increased (p = 0.021) in the tumor tissue, the expression of miR-137 was downregulated (p = 0.041) after NACT in HR positive BC. Conclusions The study revealed diferences in miR-124a and miR-373 expression after NACT in primary BC tissues. Although miRs levels did not impact the response to NACT, we found miR-124a and miR-137 levels to be related to hormonal sensitivity of BC.
Appears in Collections: Наукові видання (НН МІ)

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