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Title Correction of myocardial changes on an animal experimental model with meldonim
Authors Yarmolenkо, Olha Serhiivna  
Bumeister, Valentyna Ivanivna  
Prykhodko, Olha Oleksandrivna
Hordiienko, Olena Volodymyrivna  
Demikhova, Nadiia Volodymyrivna  
Keywords experimental model with meldonim
hypoosmolar overhydration
Type Conference Papers
Date of Issue 2022
Publisher Oxford University Press
License Creative Commons Attribution 4.0 International License
Citation O Yarmolenko, V Bumeister, O Prykhodko, O Gordienko, N Demikhova, Correction of myocardial changes on an animal experimental model with meldonim, Cardiovascular Research, Volume 118, Issue Supplement_1, June 2022, cvac066.243,
Abstract Prolonged hypoosmolar overhydration causes a volume overload necessitating cardioprotectors together with a complex of measures aimed at stabilizing the water and electrolyte balance. The content of water and electrolytes in the human body changes throughout life, so the body's response to the disorder of water and salt balance may be different depending on age. The fluid overload positively correlates with adverse outcomes in critically ill patients. One of the main tasks of modern cardiology is to find the means of leveling the influence of adverse factors on myocardium in different aged patients. The aim of our study was the determination of morphological changes in the myocardium of old laboratory animals under the influence of severe hypoosmolar hyperhydration and attempt to correct the identified changes by means of meldonium.
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