|Title||Correction of myocardial changes on an animal experimental model with meldonim|
Yarmolenkо, Olha Serhiivna
Bumeister, Valentyna Ivanivna
Prykhodko, Olha Oleksandrivna
Hordiienko, Olena Volodymyrivna
Demikhova, Nadiia Volodymyrivna
experimental model with meldonim
|Date of Issue||2022|
|Publisher||Oxford University Press|
|License||Creative Commons Attribution 4.0 International License|
|Citation||O Yarmolenko, V Bumeister, O Prykhodko, O Gordienko, N Demikhova, Correction of myocardial changes on an animal experimental model with meldonim, Cardiovascular Research, Volume 118, Issue Supplement_1, June 2022, cvac066.243, https://doi.org/10.1093/cvr/cvac066.243|
Prolonged hypoosmolar overhydration causes a volume overload necessitating cardioprotectors together with a complex of measures aimed at stabilizing the water and electrolyte balance. The content of water and electrolytes in the human body changes throughout life, so the body's response to the disorder of water and salt balance may be different depending on age. The fluid overload positively correlates with adverse outcomes in critically ill patients. One of the main tasks of modern cardiology is to find the means of leveling the influence of adverse factors on myocardium in different aged patients.
The aim of our study was the determination of morphological changes in the myocardium of old laboratory animals under the influence of severe hypoosmolar hyperhydration and attempt to correct the identified changes by means of meldonium.
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