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Title | The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics |
Authors |
Piddubnyi, Artem Mykhailovych
Kolomiiets, Olena Olehivna Danylchenko, Serhii Mykolaiovych Stepanenko, Andrii Oleksandrovych Moskalenko, Yuliia Vasylivna Moskalenko, Roman Andriiovych |
ORCID |
http://orcid.org/0000-0002-6508-0131 http://orcid.org/0000-0002-6464-4839 http://orcid.org/0000-0003-0105-0440 http://orcid.org/0000-0002-5398-0298 http://orcid.org/0000-0002-2342-0337 |
Keywords |
breast cancer microcalcification phase analysis |
Type | Article |
Date of Issue | 2023 |
URI | https://essuir.sumdu.edu.ua/handle/123456789/91007 |
Publisher | MDPI |
License | Creative Commons Attribution 4.0 International License |
Citation | Piddubnyi, A.; Kolomiiets, O.; Danilchenko, S.; Stepanenko, A.; Moskalenko, Y.; Moskalenko, R. The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics. Diagnostics 2023, 13, 737. https://doi.org/10.3390/diagnostics13040737 |
Abstract |
The detection of microcalcifications in the breast by mammography is of great importance for the early diagnostics of breast cancer. This study aimed to establish the basic morphological and crystal-chemical properties of microscopic calcifications and their impact on breast cancer tissue. During the retrospective study, 55 out of 469 breast cancer samples had microcalcifications.
The expression of the estrogen and progesterone receptors and Her2-neu showed no significant difference from the non-calcified samples. An in-depth study of 60 tumor samples revealed a higher osteopontin expression in the calcified breast cancer samples (p < 0.01). The mineral deposits had a hydroxyapatite composition. Within the group of calcified breast cancer samples, we detected six cases of colocalization of oxalate microcalcifications together with biominerals of the usual “hydroxyapatite” phase composition. The simultaneous presence of calcium oxalate and hydroxyapatite was accompanied by a different spatial localization of microcalcifications. Thus, the phase compositions of microcalcifications could not be used as criteria for the differential diagnostics of breast tumors. |
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File | Size | Format | Downloads |
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Piddubnyi_breast_cancer.pdf | 5.95 MB | Adobe PDF | 505643 |
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