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Title The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics
Authors Piddubnyi, Artem Mykhailovych  
Kolomiiets, Olena Olehivna  
Danylchenko, Serhii Mykolaiovych
Stepanenko, Andrii Oleksandrovych  
Moskalenko, Yuliia Vasylivna  
Moskalenko, Roman Andriiovych  
ORCID http://orcid.org/0000-0002-6508-0131
http://orcid.org/0000-0002-6464-4839
http://orcid.org/0000-0003-0105-0440
http://orcid.org/0000-0002-5398-0298
http://orcid.org/0000-0002-2342-0337
Keywords breast cancer
microcalcification
phase analysis
Type Article
Date of Issue 2023
URI https://essuir.sumdu.edu.ua/handle/123456789/91007
Publisher MDPI
License Creative Commons Attribution 4.0 International License
Citation Piddubnyi, A.; Kolomiiets, O.; Danilchenko, S.; Stepanenko, A.; Moskalenko, Y.; Moskalenko, R. The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics. Diagnostics 2023, 13, 737. https://doi.org/10.3390/diagnostics13040737
Abstract The detection of microcalcifications in the breast by mammography is of great importance for the early diagnostics of breast cancer. This study aimed to establish the basic morphological and crystal-chemical properties of microscopic calcifications and their impact on breast cancer tissue. During the retrospective study, 55 out of 469 breast cancer samples had microcalcifications. The expression of the estrogen and progesterone receptors and Her2-neu showed no significant difference from the non-calcified samples. An in-depth study of 60 tumor samples revealed a higher osteopontin expression in the calcified breast cancer samples (p < 0.01). The mineral deposits had a hydroxyapatite composition. Within the group of calcified breast cancer samples, we detected six cases of colocalization of oxalate microcalcifications together with biominerals of the usual “hydroxyapatite” phase composition. The simultaneous presence of calcium oxalate and hydroxyapatite was accompanied by a different spatial localization of microcalcifications. Thus, the phase compositions of microcalcifications could not be used as criteria for the differential diagnostics of breast tumors.
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