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Title Invasive Breast Carcinoma of No Special Type with Medullary Pattern: Morphological and Immunohistochemical Features
Authors Lyndin, Mykola Serhiiovych  
Hyriavenko, Nataliia Ivanivna  
Sikora, Vladyslav Volodymyrovych  
Lyndina, Yuliia Mykolaivna  
Soroka, Y.
Romaniuk, Anatolii Mykolaiovych  
ORCID http://orcid.org/0000-0003-4385-3903
http://orcid.org/0000-0002-9805-014X
http://orcid.org/0000-0002-4147-6879
http://orcid.org/0000-0002-2132-0965
http://orcid.org/0000-0003-2560-1382
Keywords breast carcinoma
triple negative breast cancer
medullary carcinoma
tumor microenvironment
tumor infiltrating lymphocyte
Type Article
Date of Issue 2022
URI https://essuir.sumdu.edu.ua/handle/123456789/98921
Publisher Turkish Journal of Pathology
License Creative Commons Attribution 4.0 International License
Citation Invasive Breast Carcinoma of No Special Type with Medullary Pattern: Morphological and Immunohistochemical Features / M. S. Lyndin et al. // Turkish Journal of Pathology. 2022. Vol. 38. № 3. P. 205-212. DOI: 10.5146/tjpath.2021.01559.
Abstract Objective: Our study investigated the morphological and immunohistochemical characteristics of invasive breast carcinoma of no special type (IBC-NST) with medullary pattern to explore the inconsistencies between the structural and clinical traits of this category of tumor. Material and Method: The breast carcinoma samples (n = 26) with medullary pattern (defined according to established criteria) were subjected to immunohistochemical assays of the following receptors: ER, PR, HER2/neu, Ki-67, p53, Bcl-2, VEGF, MMP1, E-cadherin, EGFR, Hsp70, Hsp90, CD20, CD3, CD4, CD8, CD68, CD163, CD56, CD138, MPO, S100, IgG, IgM, and PD-L1. Results: IBC-NST with medullary pattern was found to have negative expression of ER, PR, and HER2/neu; strong positive expression of Kі-67, mutant р53, Bcl-2, E-cadherin, EGFR, and PD-L1; moderate positive expression of Hsp70 and Hsp90; and low or negative expression of VEGF and MMP1. Furthermore, there was pronounced variability in the qualitative composition of tumor immune infiltrates with regards to T-lymphocytes, B-lymphocytes, macrophages, plasmocytes, and granulocytes. Conclusion: IBC-NST with medullary pattern has many unfavourable morphological and immunohistochemical prognostic characteristics, which are balanced against the pronounced protective properties of the tumor cells and the qualitative characteristics of the tumor microenvironment. These can lead to a favourable disease course despite the relatively adverse features of the carcinoma cells.
Appears in Collections: Наукові видання (НН МІ)

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