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Title | Invasive Breast Carcinoma of No Special Type with Medullary Pattern: Morphological and Immunohistochemical Features |
Authors |
Lyndin, Mykola Serhiiovych
![]() Hyriavenko, Nataliia Ivanivna ![]() Sikora, Vladyslav Volodymyrovych ![]() Lyndina, Yuliia Mykolaivna ![]() Soroka, Y. Romaniuk, Anatolii Mykolaiovych ![]() |
ORCID |
http://orcid.org/0000-0003-4385-3903 http://orcid.org/0000-0002-9805-014X http://orcid.org/0000-0002-4147-6879 http://orcid.org/0000-0002-2132-0965 http://orcid.org/0000-0003-2560-1382 |
Keywords |
breast carcinoma triple negative breast cancer medullary carcinoma tumor microenvironment tumor infiltrating lymphocyte |
Type | Article |
Date of Issue | 2022 |
URI | https://essuir.sumdu.edu.ua/handle/123456789/98921 |
Publisher | Turkish Journal of Pathology |
License | Creative Commons Attribution 4.0 International License |
Citation | Invasive Breast Carcinoma of No Special Type with Medullary Pattern: Morphological and Immunohistochemical Features / M. S. Lyndin et al. // Turkish Journal of Pathology. 2022. Vol. 38. № 3. P. 205-212. DOI: 10.5146/tjpath.2021.01559. |
Abstract |
Objective: Our study investigated the morphological and immunohistochemical characteristics of invasive breast carcinoma of no special type
(IBC-NST) with medullary pattern to explore the inconsistencies between the structural and clinical traits of this category of tumor.
Material and Method: The breast carcinoma samples (n = 26) with medullary pattern (defined according to established criteria) were subjected
to immunohistochemical assays of the following receptors: ER, PR, HER2/neu, Ki-67, p53, Bcl-2, VEGF, MMP1, E-cadherin, EGFR, Hsp70,
Hsp90, CD20, CD3, CD4, CD8, CD68, CD163, CD56, CD138, MPO, S100, IgG, IgM, and PD-L1.
Results: IBC-NST with medullary pattern was found to have negative expression of ER, PR, and HER2/neu; strong positive expression of
Kі-67, mutant р53, Bcl-2, E-cadherin, EGFR, and PD-L1; moderate positive expression of Hsp70 and Hsp90; and low or negative expression of
VEGF and MMP1. Furthermore, there was pronounced variability in the qualitative composition of tumor immune infiltrates with regards to
T-lymphocytes, B-lymphocytes, macrophages, plasmocytes, and granulocytes.
Conclusion: IBC-NST with medullary pattern has many unfavourable morphological and immunohistochemical prognostic characteristics, which
are balanced against the pronounced protective properties of the tumor cells and the qualitative characteristics of the tumor microenvironment.
These can lead to a favourable disease course despite the relatively adverse features of the carcinoma cells. |
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