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Title | In vitro evaluation of electrochemically bioactivated Ti6Al4V 3D porous scaffolds |
Authors |
Myakinin, A.
Turlybekuly, A. Pohrebniak, Oleksandr Dmytrovych ![]() Mirek, A. Bechelany, M. Liubchak, Iryna Volodymyrivna Oleshko, Oleksandr Mykolaiovych ![]() Husak, Yevheniia Volodymyrivna ![]() Korniienko, Viktoriia Volodymyrivna ![]() Leśniak-Ziółkowska, K. Dogadkin, D. Banasiuk, R. Moskalenko, Roman Andriiovych ![]() Pohorielov, Maksym Volodymyrovych ![]() Simka, W. |
ORCID |
http://orcid.org/0000-0002-9218-6492 http://orcid.org/0000-0003-2439-3243 http://orcid.org/0000-0002-2217-3717 http://orcid.org/0000-0002-5144-2138 http://orcid.org/0000-0002-2342-0337 http://orcid.org/0000-0001-9372-7791 |
Keywords |
3D printed Ti6Al4V scaffolds plasma electrolytic oxidation antibacterial coating ag nanoparticles |
Type | Article |
Date of Issue | 2021 |
URI | https://essuir.sumdu.edu.ua/handle/123456789/99188 |
Publisher | Elsevier |
License | Creative Commons Attribution 4.0 International License |
Citation | Alexandr Myakinin, Amanzhol Turlybekuly, Alexander Pogrebnjak, Adam Mirek, Mikhael Bechelany, Iryna Liubchak, Oleksandr Oleshko, Yevheniia Husak, Viktoriia Korniienko, Katarzyna Leśniak-Ziółkowska, Dmitry Dogadkin, Rafał Banasiuk, Roman Moskalenko, Maksym Pogorielov, Wojciech Simka, In vitro evaluation of electrochemically bioactivated Ti6Al4V 3D porous scaffolds, Materials Science and Engineering: C, Volume 121, 2021, 111870, ttps://doi.org/10.1016/j.msec.2021.111870. |
Abstract |
Triply periodic minimal surfaces (TPMS) are known for their advanced mechanical properties and are wrinklefree
with a smooth local topology. These surfaces provide suitable conditions for cell attachment and proliferation.
In this study, the in vitro osteoinductive and antibacterial properties of scaffolds with different minimal
pore diameters and architectures were investigated. For the first time, scaffolds with TPMS architecture were
treated electrochemically by plasma electrolytic oxidation (PEO) with and without silver nanoparticles (AgNPs)
to enhance the surface bioactivity. It was found that the scaffold architecture had a greater impact on the
osteoblast cell activity than the pore size. Through control of the architecture type, the collagen production by
osteoblast cells increased by 18.9% and by 43.0% in the case of additional surface PEO bioactivation. The
manufactured scaffolds demonstrated an extremely low quasi-elastic modulus (comparable with trabecular and
cortical bone), which was 5–10 times lower than that of bulk titanium (6.4–11.4 GPa vs 100–105 GPa). The
AgNPs provided antibacterial properties against both gram-positive and gram-negative bacteria and had no
significant impact on the osteoblast cell growth. Complex experimental results show the in vitro effectiveness of
the PEO-modified TPMS architecture, which could positively impact the clinical applications of porous bioactive
implants. |
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