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Title In vitro evaluation of electrochemically bioactivated Ti6Al4V 3D porous scaffolds
Authors Myakinin, A.
Turlybekuly, A.
Pohrebniak, Oleksandr Dmytrovych  
Mirek, A.
Bechelany, M.
Liubchak, Iryna Volodymyrivna
Oleshko, Oleksandr Mykolaiovych  
Husak, Yevheniia Volodymyrivna  
Korniienko, Viktoriia Volodymyrivna  
Leśniak-Ziółkowska, K.
Dogadkin, D.
Banasiuk, R.
Moskalenko, Roman Andriiovych  
Pohorielov, Maksym Volodymyrovych  
Simka, W.
ORCID http://orcid.org/0000-0002-9218-6492
http://orcid.org/0000-0003-2439-3243
http://orcid.org/0000-0002-2217-3717
http://orcid.org/0000-0002-5144-2138
http://orcid.org/0000-0002-2342-0337
http://orcid.org/0000-0001-9372-7791
Keywords 3D printed Ti6Al4V scaffolds
plasma electrolytic oxidation
antibacterial coating
ag nanoparticles
Type Article
Date of Issue 2021
URI https://essuir.sumdu.edu.ua/handle/123456789/99188
Publisher Elsevier
License Creative Commons Attribution 4.0 International License
Citation Alexandr Myakinin, Amanzhol Turlybekuly, Alexander Pogrebnjak, Adam Mirek, Mikhael Bechelany, Iryna Liubchak, Oleksandr Oleshko, Yevheniia Husak, Viktoriia Korniienko, Katarzyna Leśniak-Ziółkowska, Dmitry Dogadkin, Rafał Banasiuk, Roman Moskalenko, Maksym Pogorielov, Wojciech Simka, In vitro evaluation of electrochemically bioactivated Ti6Al4V 3D porous scaffolds, Materials Science and Engineering: C, Volume 121, 2021, 111870, ttps://doi.org/10.1016/j.msec.2021.111870.
Abstract Triply periodic minimal surfaces (TPMS) are known for their advanced mechanical properties and are wrinklefree with a smooth local topology. These surfaces provide suitable conditions for cell attachment and proliferation. In this study, the in vitro osteoinductive and antibacterial properties of scaffolds with different minimal pore diameters and architectures were investigated. For the first time, scaffolds with TPMS architecture were treated electrochemically by plasma electrolytic oxidation (PEO) with and without silver nanoparticles (AgNPs) to enhance the surface bioactivity. It was found that the scaffold architecture had a greater impact on the osteoblast cell activity than the pore size. Through control of the architecture type, the collagen production by osteoblast cells increased by 18.9% and by 43.0% in the case of additional surface PEO bioactivation. The manufactured scaffolds demonstrated an extremely low quasi-elastic modulus (comparable with trabecular and cortical bone), which was 5–10 times lower than that of bulk titanium (6.4–11.4 GPa vs 100–105 GPa). The AgNPs provided antibacterial properties against both gram-positive and gram-negative bacteria and had no significant impact on the osteoblast cell growth. Complex experimental results show the in vitro effectiveness of the PEO-modified TPMS architecture, which could positively impact the clinical applications of porous bioactive implants.
Appears in Collections: Наукові видання (НН МІ)

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