Impact of VDR gene polymorphism on the development of ischemic stroke in smokers and non-smokers

Abstract

Today, we have ample evidence that hormonal system of vitamin D, the main component of which is calcitriol (1α,25(OH)2D3) and receptor of vitamin D (VDR) plays an important role not only in the regulation of functional and metabolic processes in the body, but also in the development of many diseases, including cardiovascular disease. The risk factors for ischemic stroke can be divided into unregulated (age, gender, race) and susceptible (malnutrition, lack of physical activity, smoking, alcohol abuse). Smoking doubles the risk of stroke. Once you stop smoking, the risk of a stroke in you will start to decrease immediately, after five years, the risk of developing a stroke will be the same as that of non-smokers.