Protein V, a novel type-II IgG receptor from Streptococcus sp.: sequence, homologies and putative Fc-binding site.
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1992
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Abstract
We have cloned and sequenced the Fc-receptor-encoding gene, fcrV, from a group G streptococcus. Considerable sim¬ilarity was revealed between the FcRV, FcRA76 and M proteins of group A streptococci in their signal sequences and 3' termini, and between the Fc-binding regions of FcRV and FcRA76. The promoter and terminator regions showed no ho¬mology with those of the fcrA76 and M protein-encoding genes. The A1-A4 domains of FcRV (protein V) exhibit a heptapeptide repeat motif which is characteristic of α-helical coiled-coil proteins. The sequence, Ser-Asn-Arg-Ala-Ala, in the outer position, 'f' of each domain, is highly conserved and may be involved in FcR-IgG interactions.
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Keywords
recombinant DNA, nucleotide sequence, Fc receptor, protein structure, рекомбинантная ДНК, нуклеотидная последовательность, Fc рецептор, структура белка, нуклеотидна послідовність, структура білку
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Protein V, a novel type-II IgG receptor from Streptococcus sp.: sequence, homologies and putative Fc-binding site / Smirnov O.Yu., Denesyuk A.I., Zakharov M.V. et al. // Gene. - 1992. - V.120. - No.1. - P. 27–32.
Protein V, a novel type-II IgG receptor from Streptococcus sp.: sequence, homologies and putative Fc-binding site (Erratum) / Smirnov O. Yu., Denesyuk A. I., Zakharov M. V. et al. // Gene. - 1993. - V.124. - No.1. - P. 149–150.