Diagnostic value of lymph node calcification in thyroid cancer

dc.contributor.authorКурочкін, Андрій Вікторович
dc.contributor.authorКурочкин, Андрей Викторович
dc.contributor.authorKurochkin, Andrii Viktorovych
dc.contributor.authorМоскаленко, Роман Андрійович
dc.contributor.authorМоскаленко, Роман Андреевич
dc.contributor.authorMoskalenko, Roman Andriiovych
dc.date.accessioned2022-05-09T05:56:34Z
dc.date.available2022-05-09T05:56:34Z
dc.date.issued2022
dc.description.abstractThe role of pathological biomineralization (PBM) as a prognostic and diagnostic marker in thyroid cancer is continuously debated among investigators. Detection of pathological biomineralization in the lymph nodes of the neck is an alarming signal for clinicians. Typically, a lymph node with signs of calcification is a symptom of papillary thyroid cancer. The lymph node contains such a form of calcification as psammoma bodies in such cases. Psammoma bodies of relatively large size (more than 200 μm) can be detected by ultrasound. Our study aims to study the crystal-chemical and phase characteristics of calcifications of metastatic lymph nodes in thyroid cancer to develop promising methods of early diagnosis. Materials and methods. Several complex research methods have been conducted for a deeper understanding of the pathological biomineralization of metastatic lymph nodes in thyroid cancer, such as macroscopic examination, ultrasound diagnostics, detection of strict lymph node, histological, histochemical, and electron microscopic (scanning electron microscopy, X-ray diffraction, and transmission electron microscopy). Our study found that the main component of pathological biomineral deposits is calcium phosphate compounds. The Ca / P ratio corresponds to the characteristic features of hydroxyapatite. A significant proportion of β-tricalcium magnesium phosphate was also detected in some cases. The specific plate structure and the known phase and crystal-chemical composition of psammoma bodies can be the point of application of searches for their early detection using the latest diagnostic methods with high resolution. Conclusion. Our study demonstrated the significance of PBM in lymph nodes as a diagnostic symptom of papillary thyroid cancer patients. The presence and extent of PBM in the lymph nodes should be considered a metastasis of papillary thyroid cancer. The study of the structure, physicochemical, phase composition of lymph node calcifications, and visualization features is promising given the possible practical application for early diagnosis of metastases of papillary thyroid cancer.en_US
dc.description.sponsorshipThis research has been performed with the financial support of grants of the Ministry of Education and Science of Ukraine No. 0112U100471 “Condition of mineralized tissues using new composites with Ag + and Cu2 + nanoparticles”.en_US
dc.identifier.citationKurochkin A, Moskalenko R. Diagnostic value of lymph node calcification in thyroid cancer. Theoretical and practical aspects of the development of modern scientific research: monograph / ed. Anita Jankovska. Riga : Izdevniecība “Baltija Publishing”, 2022. P. 194–212. DOI: https://doi.org/10.30525/978-9934-26-195-4-23en_US
dc.identifier.sici0000-0002-2342-0337en
dc.identifier.urihttps://essuir.sumdu.edu.ua/handle/123456789/87724
dc.language.isoenen_US
dc.publisherBaltija Publishingen_US
dc.rights.uricneen_US
dc.subjectрак щитоподібної залозиen_US
dc.subjectрак щитовидной железыen_US
dc.subjectthyroid canceren_US
dc.subjectсторожовий лімфатичний вузолen_US
dc.subjectсторожевой лимфатический узелen_US
dc.subjectsentinel lymph nodeen_US
dc.subjectбіомінералізаціяen_US
dc.subjectбиоминерализацияen_US
dc.subjectbiomineralizationen_US
dc.subjectпсаммомні тільцяen_US
dc.subjectпсаммоные тельцаen_US
dc.subjectpsammoma bodiesen_US
dc.subjectгідроксиапатитen_US
dc.subjectгидроксиапатитen_US
dc.subjecthydroxyapatiteen_US
dc.titleDiagnostic value of lymph node calcification in thyroid canceren_US
dc.typeMonographen_US

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