Giant-cell epulis: immunohistochemical analysis of MGMT, p53, OPN and ММР-1

Abstract

Object: The object of this study was to analyze the expression of MGMT, p53, OPN and ММР-1 in giant-cell epulis. Methods: 10 giant-cell epulis were evaluated for expression of MGMT, p53, OPN and ММР-1 by immunohistochemistry. Results: Strong giant-cell positivity for MGMT was observed in 96.9±0.5% (P < 0.05). Strong mesenchymal immunoreactivity for MMP-1 was figured in giant-cell, 75.9±1.33% and in the stroma 54.12±1.36% (P<0.05). Immunoreactivity for OPN was fixed in the giant-cell of epulis 15.77±1.8%., positivity for p53 was found in 5.67±0.32% of giant-cell contrast and in the stroma 0%. Conclusion: MGMT, p53 and OPN may play important roles in the biology of giant-cell epulis. Furthermore, the ММР-1 of these proteases at higher levels in giant-cell epulis may help to explain invasion in bone matrix. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/31872