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Title Fluorescent Glycine-Coated Silver Nanoparticles as Bio-Imaging Agents for the Neural Stem Cells
Authors Kravets, V.V.
Almemar, Z.
Kotko, A.V.
Dmytruk, I.M.
Pinchuk, A.O.
Keywords silver nanoparticles
stem cells
toxicity
bio-imaging
surface plasmon resonance
photoluminescence
Type Conference Papers
Date of Issue 2015
URI http://essuir.sumdu.edu.ua/handle/123456789/42509
Publisher Sumy State University
License
Citation Fluorescent Glycine-Coated Silver Nanoparticles as Bio-Imaging Agents for the Neural Stem Cells [Текст] / A.O. Pinchuk, V.V. Kravets, Z. Almemar et al. // Nanomaterials: Applications & Properties (NAP-2015) : Proceedings of the International Conference. — Sumy : Sumy State University, 2015. — V.4, No2. — 02NABM02.
Abstract We study experimentally the photoluminescence of small glycine-coated silver nanoparticles and their application as the bio-imaging markers of the neural stem cells. In addition we study nanoparticle’s toxic effects on the neural stem cells. Glycine-coated silver nanoparticles were synthesized using a thermal reduction of silver nitrate in a glycine matrix and size-separated via centrifugation. The properties of the nanoparticles were characterized using transmission electron microscopy, extinction and photoluminescence spectroscopy. Our results indicate that the nanoparticles have deleterious effects on the cells and showed an amplified increase in their death rates. In fixed cells the particles penetrate the membranes within an hour and 25 minutes of incubation, but do not penetrate into the body of the cell.
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