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Title Analysis of Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene K121Q Polymorphism Association with Some Risk Factors of Atherosclerosis in Patients with Acute Coronary Syndrome
Authors Ataman, Oleksandr Vasylovych  
Harbuzova, Viktoriia Yuriivna  
Obukhova, Olha Anatoliivna  
Dubovyk, Yevhen Ivanovych  
Keywords ектонуклеотид пірофофотази/фосфодіестерази 1
эктонуклеотид пирофофотазы/фосфодиестеразы 1
ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1)
гострий коронарний синдром
острый коронарный синдром
acute coronary syndrome
поодинокий поліморфізм
однонуклеотидный пориморфизм
single nucleotide polymorphism
фактори ризику
факторы риска
risk factors
Type Article
Date of Issue 2018
URI https://essuir.sumdu.edu.ua/handle/123456789/80865
Publisher Springer
License In Copyright
Citation Ataman, A.V., Harbuzova, V.Y., Obukhova, O.A. et al. Analysis of Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene K121Q Polymorphism Association with Some Risk Factors of Atherosclerosis in Patients with Acute Coronary Syndrome. Cytol. Genet. 52, 127–131 (2018). https://doi.org/10.3103/S0095452718020020
Abstract The present study was performed to investigate whether common single-nucleotide polymorphism K121Q (rs1044498) of the ENPP1 gene is associated with the known risk factors of atherosclerosis (overweight, dyslipoproteinemia, hypertension, diabetes, smoking, and hypercoagulability) in persons with acute coronary syndrome. Venous blood of 118 patients was genotyped for the polymorphism by PCR and restriction fragment length polymorphism method. In patients divided into two subgroups according to their genotype (KK and KQ + QQ), the statistically significant differences were revealed only for plasma LDL-cholesterol level and fibrinolytic activity. The carriers of minor allele (KQ + QQ) had lower LDL-cholesterol concentration and the time of fibrinolysis than the major allele homozygotes (KK). The division of patients into subgroups according to presence or absence of some risk factors for atherosclerosis showed no statistically significant differences between K121Q genotype distributions for any of the comparison.
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