Please use this identifier to cite or link to this item: https://essuir.sumdu.edu.ua/handle/123456789/80865
Or use following links to share this resource in social networks: Recommend this item
Title Analysis of Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene K121Q Polymorphism Association with Some Risk Factors of Atherosclerosis in Patients with Acute Coronary Syndrome
Authors Ataman, Oleksandr Vasylovych  
Harbuzova, Viktoriia Yuriivna  
Obukhova, Olha Anatoliivna  
Dubovyk, Yevhen Ivanovych  
ORCID http://orcid.org/0000-0002-1941-740X
http://orcid.org/0000-0001-7183-6997
http://orcid.org/0000-0002-2104-8412
http://orcid.org/0000-0002-6720-8397
Keywords ектонуклеотид пірофофотази/фосфодіестерази 1
эктонуклеотид пирофофотазы/фосфодиестеразы 1
ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1)
гострий коронарний синдром
острый коронарный синдром
acute coronary syndrome
поодинокий поліморфізм
однонуклеотидный пориморфизм
single nucleotide polymorphism
фактори ризику
факторы риска
risk factors
Type Article
Date of Issue 2018
URI https://essuir.sumdu.edu.ua/handle/123456789/80865
Publisher Springer
License In Copyright
Citation Ataman, A.V., Harbuzova, V.Y., Obukhova, O.A. et al. Analysis of Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene K121Q Polymorphism Association with Some Risk Factors of Atherosclerosis in Patients with Acute Coronary Syndrome. Cytol. Genet. 52, 127–131 (2018). https://doi.org/10.3103/S0095452718020020
Abstract The present study was performed to investigate whether common single-nucleotide polymorphism K121Q (rs1044498) of the ENPP1 gene is associated with the known risk factors of atherosclerosis (overweight, dyslipoproteinemia, hypertension, diabetes, smoking, and hypercoagulability) in persons with acute coronary syndrome. Venous blood of 118 patients was genotyped for the polymorphism by PCR and restriction fragment length polymorphism method. In patients divided into two subgroups according to their genotype (KK and KQ + QQ), the statistically significant differences were revealed only for plasma LDL-cholesterol level and fibrinolytic activity. The carriers of minor allele (KQ + QQ) had lower LDL-cholesterol concentration and the time of fibrinolysis than the major allele homozygotes (KK). The division of patients into subgroups according to presence or absence of some risk factors for atherosclerosis showed no statistically significant differences between K121Q genotype distributions for any of the comparison.
Appears in Collections: Наукові видання (НН МІ)

Views

China China
9477746
Côte d’Ivoire Côte d’Ivoire
1
Germany Germany
63351
Greece Greece
1
Ireland Ireland
2816305
Lithuania Lithuania
1
Netherlands Netherlands
151
Singapore Singapore
1
Sweden Sweden
1279
Ukraine Ukraine
162040050
United Kingdom United Kingdom
49892862
United States United States
1507805901
Unknown Country Unknown Country
1
Vietnam Vietnam
2559

Downloads

Canada Canada
1
China China
1059217285
Germany Germany
386334355
India India
24529
Ireland Ireland
446998
Lithuania Lithuania
1
Netherlands Netherlands
1
Turkey Turkey
1
Ukraine Ukraine
386334355
United Kingdom United Kingdom
1
United States United States
1507805902
Vietnam Vietnam
1

Files

File Size Format Downloads
Ataman_coronary_syndrome.pdf 353,7 kB Adobe PDF -954803866

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.