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Title The role of leptinresistance in the pathogenesis of obesity in pregnant women
Authors Smiianov, Vladyslav Anatoliiovych  
Fartushok, T.V.
Rudenko, L.A.
Fartushok, N.V.
Keywords leptin
glucose
cholesterol
C-peptide
HOMA index
Type Article
Date of Issue 2022
URI https://essuir.sumdu.edu.ua/handle/123456789/89617
Publisher Aluna Publishing
License Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International
Citation Smiianov VA, Fartushok TV, Rudenko LA, Fartushok NV. THE ROLE OF LEPTINRESISTANCE IN THE PATHOGENESIS OF OBESITY IN PREGNANT WOMEN. Wiad Lek. 2022;75(5 pt 2):1274-1283. doi: 10.36740/WLek202205208.
Abstract The aim: To investigate the relationship between leptin resistance, lipid and carbohydrate metabolism, blood pressure in obese pregnant women. Materials and methods: Under observation were 65 women (main group) with obesity (I degree -27 women, II degree - 24 women, III degree - 14 women) in the II trimester of pregnancy, who were hospitalized in the Department of Pathology of Pregnancy KNP «Maternity Clinical house №1 ”in Lviv during 2017-2020 on preeclampsia of varying severity, which were sent for inpatient treatment by women’s clinics. The control group consisted of 30 healthy pregnant women without obesity. Results: Serum leptin in obese women was directly correlated with BMI (r = 0.66, p<0.001), body weight (r = 0.29, p<0.05), total cholesterol (cholesterol) (r = 0, 37,p<0,009), low density lipoproteins (LDL cholesterol) (r = 0.33, p<0.05) and inversely with high density particles (HDL cholesterol) (r = -0.37, p<0.02 ). Studies of carbohydratemetabolism indicate the following correlation coefficients of BMI with glucose level r = 0.351; p<0,001, BMI with the level of C-peptide r = 0,450; p<0,001, BMI with HOMA index r = 0,1504; p = 0.036. Inverse correlations of C-peptide were detected with the level of P (r = -0.169; p = 0.025). Conclusions: The discovery of the relationship between leptin resistance, lipid and carbohydrate metabolism, blood pressure indicates the possibility of using signs of leptin resistance to prevent complications during pregnancy in the second trimester.
Appears in Collections: Наукові видання (МІ)

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