Metabolic markers of insulin resistance in Iraqi type 2 diabetes mellitus patients infected with H. pylori

Abstract

Introduction and Aim: People with diabetes mellitus are typically more vulnerable to long-term infections. On the other hand, reports regarding the connection between type II diabetes and H. pylori infection have been inconsistent. The researchers in this study set out to determine how common Helicobacter pylori infection is among Iraqi diabetics. Materials and Methods: Enzyme-linked immunosorbent assays (ELISA) were used to assess the levels of physiological markers in blood samples obtained from H. pylori-infected individuals in Iraq. The investigation also included patients with type 2 DM without H. pylori infection, who fulfilled the role of the controls. Results: Compared to the control group of healthy individuals, blood samples from Iraqi patients with diabetes and H. pylori infection exhibited a statistically significant increase (P < 0.01). Diabetic patients who were additionally infected with H. pylori were found to have a higher risk of insulin resistance, obesity, high levels of low-density lipoprotein (LDL), fasting blood sugar (FBS), C-reactive protein (CRP), cholesterol, triglycerides, and higher body mass index (BMI) compared to those without the infection. The study's findings indicate that there was no significant difference in the severity of insulin resistance between patients with Helicobacter pylori infection and those with diabetic mellitus (DM). Conclusion: This study investigated the impact of H. pylori infection on metabolic parameters in Iraqi patients with type 2 diabetes. The results showed a significant association between H. pylori infection and elevated levels of HbA1c, fasting blood sugar, and BMI. Additionally, the study found a higher prevalence of H. pylori infection in diabetic patients with a history of smoking. These findings highlight the importance of considering H. pylori infection in the management of type 2 diabetes.