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Title Correlation between Asprosin and Spexin levels in Iraqi children with growth hormone deficiency
Authors Jawad, G.S.
Ghannawi, L.A.
Hamad, A.L.
Gharab, K.
Abdullah, W.H.
ORCID
Keywords asprosin
spexin
GHD
IGF-1
iraqi children
Type Article
Date of Issue 2025
URI https://essuir.sumdu.edu.ua/handle/123456789/99789
Publisher Sumy State University
License Creative Commons Attribution 4.0 International License
Citation Jawad GS, Ghannawi LA, Hamad AL, Gharab K, Abdullah WH. Correlation between Asprosin and Spexin levels in Iraqi children with growth hormone deficiency. East Ukr Med J. 2025;13(2):536-543. DОI: https://doi.org/10.21272/eumj.2025;13(2):536-543
Abstract Introduction: Growth hormone deficiency (GHD) is an endocrine disorder that causes a reduction in the synthesis of growth hormone (GH) in children, leading to short stature and delayed puberty. Insulin-like growth factor-I (IGF-1) plays a critical role in the growth-promoting effect of GH. IGF-1 levels provide information about the body’s natural release of GH. Asprosin (ASP) is a modernly recognized adipokine produced from adipose tissue linked to metabolic disorders like obesity and diabetes. Spexin (SPX) is a newly discovered adipokine implicated in various homeostatic functions, including metabolism, endocrine processes, and GH production. This study suggests a special relationship between GH, ASP, and SPX in GHD children. Methods: investigates the potential correlation between ASP and SPX in 90 children, 40 with GHD, and 50 healthy controls. Levels of growth hormone, insulin-like growth factor-1, and vitamin D3 were measured in both groups. SPX and ASP levels were measured by using enzyme-linked immunoassay. Results: biochemical parameters between the patient and control group showed significant differences in Hb, Vit.D3, ASP, SPX, and GH p< 0.050, In the correlation study, GH showed a significant negative correlation with ASP, SPX, and Hb (p=0.015, p=0.000 and p=0.024 respectively), but show a positive correlation with D3. Conclusion: ASP could be one of the underlying factors contributing to GHD through influencing metabolic processes linked to GH regulation. Also, differences in SPX levels may play a role in the etiology of GHD, as SPX is proven to be expressed in all endocrine glands.
Appears in Collections: Східноукраїнський медичний журнал

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