Evaluation of methotrexate toxicity
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Date
2023
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Izdatel'stvo Elm
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Abstract
The article analyzes literary sources on the study of the toxic effects of methotrexate in the treatment of various diseases and examines scientific data on methods of preventing their development. According to the literary information, the main toxic effects of methotrexate manifest as damage to the liver, kidneys, bone marrow, lungs, digestive system, and skin. Methotrexate exhibits pronounced embryotoxic and teratogenic effects. Monitoring of blood test parameters and selection of an optimal dose will minimize methotrexate toxic effects and help in achieving success in the treatment.
Keywords
methotrexate, toxisity, side effects, clinical evaluation, bone marrow disease, teratogenesis, digestive system disease, embryotoxicity, skin disease, lung disease, liver disease, kidney disease
Citation
Riabenko T. V., Hula V. I., Korenkov O. V., Ponyrko A. A., Teslyk T. P. et al. Evaluation of methotrexate toxicity. Azerbaijan Medical Journal. 2023;(4).141-146. DOI: 10.34921/amj.2023.4.020.